Microsoft has published a hotfix for the problem of the calibration curves unloading when the secure desktop launches in Vista. The fix is included in security update MS08-025. The calibration fix is only installed on Vista SP1 and later. If MS08-025 is installed on a non-SP1 system, the calibration fix is not installed. 

If this fix fails to correct the problem, Windows Defender could be the culprit.  Try shutting off Windows Defender by following these steps:

1. Navigate to Control Panel and then double click on "Windows Defender" to open it.
2. Select "Tools" and then "Options".
3. Scroll to the bottom of the page of options and uncheck the "Use Windows Defender" check box in the "Administrator options" section.   
4. Click on "Save" and then "Close" in the resulting Windows Defender information window.
5. Restart the the computer to turn off Windows Defender and check to see if the monitor profile loads automatically.

The Windows Firewall could also be causing the OS to lose the profile.  Use the following instructions to set exceptions to "CalibrationLoader.exe" in i1Match 3:

1. Navigate to Control Panel and then double click on "Windows Firewall" to open it.
2. If the firewall is on, select "change settings" and then click on the "Exceptions" tab.
3. Select "Add Program" and then "Browse".
4. Click on "Computer" and then navigate to the "CalibrationLoader.exe" at: C:\Program Files (will be "Program Files (x86)" on 64-bit Vista)\GretagMacbeth\i1\Eye-One Match 3\Calibration Loader 
5. Select the "CalibrationLoader.exe" > "Open" > "OK" > and "OK" to set the exception to the firewall.
6. Restart the PC to allow exceptions to start properly.

Also with i1Match3 users, check to see if "Logo Calibration Loader" is in the Startup menu (Windows Start > All Programs > Startup).  If not, save a shortcut on the desktop to the "CalibrationLoader.exe" at: C:\Program Files (will be "Program Files (x86)" on 64-bit Vista)\GretagMacbeth\i1\Eye-One Match 3\Calibration Loader.  Drag the shortcut to the Startup menu.  

Finally, if all else fails, you can manually re-launch your calibration curve by going to Start > Startup and double-clicking the correct calibration loader for your profling application.